The first of two consecutive prime time games for the New England Patriots takes place tonight when they host the Buffalo Bills and try to improve to a perfect 10-0.

This will be the 112th meeting between the two teams with the Patriots holding the all-time series lead 68-42-1 including their 42-32 win back on week 2 of the season. In the 13 times the Pats and Bills have played at Gillette Stadium the Pats have posted a 12-1 record.

Much attention is also given to the coaching match-up in this one as Rex Ryan has not had the most success against the Patriots. When you take his time with the New York Jets and now the Bills, the Patriots are 10-4 all-time against Ryan's teams.

Cornerback Justin Coleman and linebacker Jamie Collins have been ruled our for this game along with Julian Edelman who suffered a broken foot last week. Offensive lineman Tre' Jackson, Sebastian Vollmer and Marcus Cannon are all listed as questionable.

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