A great start for the Boston Red Sox Wednesday night and then everything went off track. A frustrating loss in Toronto 6-4 left everyone wondering if the for sale sign is now up on several players as the trade deadline approaches.

David Ortiz whacked a 3-run home run in the first inning to get the Sox off and running. But Clay Buchholz gave up three runs in the bottom of the first.

The Sox grabbed another lead in the fifth only to have Buchholz give up two runs in the sixth.

Buchholz gave up five runs in six innings. He walked four and struck out just one.

Check out the one highlight of the night for the Sox, the Papi first inning blast...